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If you believe in the power of what science can do, 加入澳门葡京赌博游戏,努力突破科学的界限,提供改变生活的药物.
基因组学——绘制所有人类基因及其相互作用的图谱——已经改变了药物发现和临床研究的游戏规则, underpinning the transformative shift towards precision medicine. But beyond the genome lie the dynamic realms of the transcriptome, 蛋白质组和代谢组——大量未开发的丰富信息库,如果将它们联系起来,可以告诉澳门葡京赌博游戏更多关于疾病驱动因素的信息. Multi-omics is the integration of these datasets which, through advances in technology, is now beginning to reveal new insights.
To unveil promising new drug targets, 真正了解由基因组编程的下游“基因组”是至关重要的, namely the transcriptome (the totality of RNA readouts), 蛋白质组(产生的蛋白质总数)和代谢组(产生的代谢产物总数). 基因组学提供了一个静态视图——DNA“蓝图”——而其他“基因组”是动态的,在不同的条件下会发生变化. The transcriptome, for example, 能揭示细胞内每个基因的开启或关闭程度吗, akin to a dimmer switch.
Through bioinformatics and artificial intelligence (AI), 澳门葡京赌博游戏可以使用这些组学数据来创建健康的整个层次系统的多维模型, diseased and treated states. 这对药物发现具有深远的影响,使澳门葡京赌博游戏有可能发现潜在的新药物靶点并验证它们. We can anticipate toxicity. 澳门葡京赌博游戏还可以开发用于下游伴随诊断的生物标志物. Ultimately, 在机器学习和人工智能的帮助下,多组学是澳门葡京赌博游戏整个组织预测科学的推动者, 澳门葡京赌博游戏可以用它来更准确地预测药物分子在细胞中的作用.
Within transcriptomics, 澳门葡京赌博游戏采用最先进的技术,目的是产生智能, dynamic and unbiased data. 以及单细胞测序(一种在微环境下对单个细胞的RNA进行测序的技术), these include:
多组学仪器每隔一到两年就在进步,每次澳门葡京赌博游戏都比以前多取得25%的进展, like zooming in on a Google map. And it’s not only sensitivity and resolution that’s increasing. 速度、吞吐量和特异性也是如此,每次分析所需的材料越来越少. It’s making the impossible possible and the possible easier. Powered by technological innovation, 多组学被证明是所有发现科学中最丰富的数据来源之一.
As we increase the precision and the granularity of the data, it’s like going from DVD to Blu-ray to 4K disks. 或者从光学显微镜到电子显微镜再到原子显微镜, but in the future we’ll have subatomic microscopy. The opportunity is limitless.
If you believe in the power of what science can do, 加入澳门葡京赌博游戏,努力突破科学的界限,提供改变生活的药物.
We know that however innovative our science, however effective our medicines and delivery, to achieve all we want to achieve, we cannot do it alone.
Veeva ID: Z4-66301
Date of preparation: July 2024